ADME

In vitro and in vivo experiments to assess the metabolism and pharmacokinetic properties of a given test item

Caco-2 permeability: The assay performed to predict the human intestinal absorption of a drug molecule

CYP profiling/liability: Identifying the CYP isozymes involved in the metabolism of a test item. The induction and inhibition of a drug molecule towards CYP isozymes are determined.

Liver microsomes stability: In vitro metabolic stability experiment performed with mice, rat and human microsomes/hepatocytes

Blood plasma kinetics: Single dose pharmacokinetic study performed in rodents and rabbit to determine AUC, Cmax, T1/2 etc.

Bioavailability studies: To determine oral availability of a test item versus its intravenous availability

Tissue distribution studies: In vivo study to assess the distribution of a test item into various tissues

In vivo metabolism studies: Metabolism experiment performed in a given animal model for a test item and the metabolites are characterized

Bioanalytical method development: Developing a new bioanalytical method for the test item