Microbiology

A range of in vitro and in vivo studies can be performed to assess the potential of a given NCE for antibiotic therapy

MIC: Minimum inhibitory concentration determination by microbroth dilution and agar dilution method as per CLSI standard against Gram positive and Gram negative pathogens.

Culture collection: We have a good collection of ATCC and clinical strains of Indian origin

Kill kinetics: Cidal or static property of a given test item is determined

Post antibiotic effect: Effect of test item on bacteria and the time taken for the bacteria to recover from the antibiotic exposure are determined

Mutant prevention concentration: The potential of a target towards resistance development is assessed by studying the frequency of mutation