Anthem BioPharma | Anthem Cellutions

Natural Product Inspired Libraries (Proprietary)

Natural products are an attractive source of diverse functionalities that exhibit potent biological activities and many new drugs have been designed based on natural products.

As the demand for new chemical entities (NCE) towards different therapeutic areas is ever growing, virtual libraries derived from natural product-like scaffolds would be an ideal platform to identify druggable compounds.

Anthem has developed a novel idea of generating scaffolds inspired by natural products. The core structure of natural products is modified by introduction of drug-like functionality, removal of toxicophores and so on. Subsequently suitable functional groups are added to the core structure to generate scaffolds which could be amenable to library generation of novel compounds. These scaffolds are also carefully chosen based on their synthetic feasibility.

This unique concept of building scaffolds derived from natural product has provided access to a diverse collection of virtual library compounds. This collection of compounds would serve as an ideal starting point for any high throughput screening (HTS) program involving search for pharmacologically active molecules. Currently Anthem has a collection of about 100,000 virtual library compounds derived from natural products. These are available to clients on mutually agreed terms